Phosphomolybdic acid-Al2O3: A mild, efficient, heterogeneous and reusable catalyst for regioselective opening of oxiranes with amines to β-amino alcohols

Epoxides undergo smoothly ring-opening reaction with various amines catalyzed by solid acid containing phosphomolybdic acid-neutral alumina under mild reaction conditions. All the reactions were carried out at room temperature to afford the corresponding β-amino alcohols in excellent yields and with high regioselectivity. The catalyst was recovered and reused for further reactions with very good efficiency.

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