کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6812117 | 1433787 | 2018 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association between B vitamins and schizophrenia: A population-based case-control study
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
To explore the association between schizophrenia and six types of B vitamins, including choline, biotin, riboflavin, pyridoxamine, pyridoxine and nicotinamide, based on the hydrophilic interaction liquid chromatography column (HILIC) Liquid Chromatography-Mass Spectrometry (LC-MS) platform. We conducted the case-control study between November 2015 and September 2016 in Weifang, Shandong Province, China. Blood samples from 128 cases of schizophrenia and 101 controls were collected, and B vitamin were measured by LC-MS coupled with HILIC. The HILIC UPLC-MS based analysis of serum B vitamins levels from 128 cases (30 cases with first-episode, 98 cases with relapse) and 101 controls were performed. The results indicated that lower pyridoxine level and schizophrenia was related. (total cases versus controls: β= â0.215, 95% CI: â0.271, â0.125, p < 0.001; first-episode cases versus controls: β = â0.190, 95% CI: â0.277, â0.103, p < 0.001). Higher nicotinamide level was also associated with schizophrenia after adjusting confounders (β = 0.343, 95% CI: 0.022, 0.664, p = 0.036). Other four B vitamins, including biotin, riboflavin, pridoxamine and choline, were showed no statistically difference in cases versus controls, first episode cases versus relapse cases. Two types of B Vitamins, pyridoxine and nicotinamide, show significant association with the schizophrenia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 259, January 2018, Pages 501-505
Journal: Psychiatry Research - Volume 259, January 2018, Pages 501-505
نویسندگان
Bing Cao, Xiao-Yu Sun, Chuan-Bo Zhang, Jing-Jing Yan, Qian-Qian Zhao, Si-Yu Yang, Lai-Lai Yan, Ning-hua Huang, Jing Zeng, Jie-Ying Liao, Jing-Yu Wang,