کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6813226 545643 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neuropsychological, electrophysiological and neurological impairments in patients with obsessive compulsive disorder, their healthy siblings and healthy controls: Identifying potential endophenotype(s)
ترجمه فارسی عنوان
اختلالات عصب شناختی، الکتروفیزیولوژیک و عصبی در بیماران مبتلا به اختلال وسواسی اجباری، خواهران و برادران سالم و کنترل سالم: شناسایی اندوفنوتایپ بالقوه (ها)
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی
The etiology of obsessive-compulsive disorder (OCD) has not been clarified. This study aimed to investigate the cognitive, neurological, electrophysiological functions which are reflected in executive functions, memory, visuospatial integration; neurological examination and auditory event related potentials (AERP) (N100, N200, P200 and P300) in patients with OCD, their siblings, and control subjects and to determine potential endophenotypic markers. Thirty-three patients with OCD, 18 siblings and 21 controls; matched for age, gender and years of education were included. Yale Brown Obsessive Compulsive Symptoms Checklist Scale, Hamilton Depression-Rating Scale, an exhaustive neuropscyhological test battery and Neurological Evaluation Scale were administered. Their AERP recordings were obtained. Executive functions and visuospatial integration were highly impaired in patients and slightly in their siblings compared to controls. P200 amplitude was sorted as siblings>patients>controls. P300 amplitude was sorted as patients
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 240, 30 June 2016, Pages 110-117
نویسندگان
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