کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6813238 | 545897 | 2016 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Analysis of the association of VIPR2 polymorphisms with susceptibility to schizophrenia
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Analysis of the association of VIPR2 polymorphisms with susceptibility to schizophrenia Analysis of the association of VIPR2 polymorphisms with susceptibility to schizophrenia](/preview/png/6813238.png)
چکیده انگلیسی
In a previous study, we confirmed that copy number variants (CNVs) within the VIPR2 gene in Han Chinese individuals exhibit an increased risk of schizophrenia (SCZ). Herein, we further analyzed the association of eight tagged single nucleotide polymorphisms (tagSNPs) from the HapMap database with SCZ susceptibility. However, we found no significant positive signals in overall association and haplotypes analyses. Interestingly, significant SNP-SNP interaction signals associated with the risk of SCZ were observed using Multifactor Dimensionality Reduction (MDR) analysis. Furthermore, the 'CC' genotype of the VIPR2 gene was nominally associated with an increased risk of SCZ in male patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 241, 30 July 2016, Pages 104-107
Journal: Psychiatry Research - Volume 241, 30 July 2016, Pages 104-107
نویسندگان
Chunhui Jin, Zhenhe Zhou, Weidong Li, Fuquan Zhang, Jianmin Yuan, Xiaowei Liu, Zaohuo Cheng,