کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6813619 | 545648 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Obtaining employment as an anchor for estimating the minimum clinically important difference on the Positive and Negative Syndrome Scale (PANSS) in schizophrenia
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
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چکیده انگلیسی
Statistical differences on clinical scales are often used to compare the effectiveness of treatments. However, statistical significance does not necessarily indicate clinical significance. The minimum clinically important difference (MCID) refers to clinically meaningful treatment differences. This study estimates the MCID of the Positive and Negative Syndrome Scale (PANSS) by anchoring the change in scores to an objective clinical outcome: employment. This secondary analysis compared PANSS score change from baseline among 1049 non-working individuals with schizophrenia, who were followed and categorized as either having not worked, worked 1-10 days, or worked >10 days at 15 or 18 months. The difference in change in average PANSS Total scores between participants who did not work and those who worked 1-10 days (4.25 points) and >10 days (8.30) were statistically significant. This study estimates the MCID for the PANSS to be between 4.25 and 8.30 Total points. This study revealed significant differences in PANSS score changes between participants who did and did not work. Using employment, an objective and clinically meaningful change in health status, to determine the MCID of PANSS resulted in estimates lower than previously reported. MCID estimates vary across methods but using objective anchors increases face validity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 238, 30 April 2016, Pages 304-309
Journal: Psychiatry Research - Volume 238, 30 April 2016, Pages 304-309
نویسندگان
Meaghan A. Leddy-Stacy, Robert Rosenheck,