Sporadic and familial subgroups of schizophrenia do not differ on dense array spontaneous gamma oscillatory activity

Genetic variations and developmental insults independently have been proposed to underlie aberrant gamma activity in schizophrenia. We investigated differences in spectral power in gamma (30-100 Hz) frequency in patients with familial and sporadic schizophrenia. Subjects underwent resting-awake EEG recording on 192 channels. The two patient subgroups did not significantly differ in any of the gamma bands and regions. We conclude that complex gene-environment interactions are responsible for the limited power of familial-sporadic distinction in schizophrenia.