کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6817543 | 1433948 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of oxytocin in the ventral tegmental area in social reinforcement
ترجمه فارسی عنوان
نقش اکسیتوسین در منطقه قاعده شکمی در تقویت اجتماعی
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کلمات کلیدی
Social motivation - انگیزه اجتماعیSocial salience - اهمیت اجتماعیSocial interaction - تعامل اجتماعیDopamine - دوپامینsocial behavior - رفتار اجتماعیMesolimbic dopamine system - سیستم دوپامین MesolimbicSocial cognition - شناخت اجتماعیoperant - عملیاتNeuropeptides - نوروپپتیدهاvasopressin - وازوپرسینSocial reward - پاداش اجتماعی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
چکیده انگلیسی
The rewarding properties of social interactions play a critical role in the development and maintenance of social relationships, and deficits in social reward are associated with various psychiatric disorders. In the present study, we used a novel Operant Social Preference (OSP) task to investigate the reinforcing properties of social interactions under conditions of high or low reward value, and high or low behavioral effort in male Syrian hamsters. Further, we investigated the role of oxytocin (OT) in a key structure of the mesolimbic reward system, the ventral tegmental area (VTA), in mediating the reinforcing properties of social interaction. Adult male hamsters were placed in a three-chambered apparatus, and allowed access to either a social chamber containing an unrestrained conspecific or a non-social chamber, by pushing through a one-way entry, vertical-swing door. Increasing the duration of social interaction (reward value) decreased the frequency of entering the social interaction chambers, whereas decreasing the duration of social interaction conversely increased the frequency of entries. Moreover, increasing behavioral effort required to access social interaction decreased the frequency of entries, especially under conditions when the duration of social interaction was only 5â¯s. OT injected into the VTA decreased the frequency of entering social interaction chambers in a manner similar to that observed when duration was increased, whereas injection of an OT receptor antagonist in the VTA increased the frequency of seeking social interaction. Taken together, these data support the hypothesis that activation of OT receptors in the VTA are critical for the reinforcing properties of social interactions. Furthermore, social interactions may exhibit duration and cost dependent reinforcing effects on behavior similar to those observed with food and drugs of abuse.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychoneuroendocrinology - Volume 95, September 2018, Pages 128-137
Journal: Psychoneuroendocrinology - Volume 95, September 2018, Pages 128-137
نویسندگان
Johnathan M. Borland, Kymberly N. Grantham, Lauren M. Aiani, Kyle J. Frantz, H. Elliott Albers,