کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6817869 | 547064 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
β-hydroxybutyrate, pyruvate and metabolic profiles in patients with schizophrenia: A case control study
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کلمات کلیدی
β-hydroxybutyratePANSSHDL-CLDL-CSchizophrenia - اسکیزوفرنی یا شیزوفرنیKetone body - بدن کتونBiomarker - بیومارکرWorld Health Organization - سازمان بهداشت جهانیMetabolic syndrome - سندرم متابولیکbody mass index - شاخص توده بدنBMI - شاخص توده بدنیMetabolite - متابولیتpositive and negative syndrome scale - مقیاس مثبت و منفی سندرمMINI - مینیMini International Neuropsychiatric Interview - مینی اینترنشنال بین المللی عصبیHigh-density lipoprotein-cholesterol - کلسترول لیپوپروتئین با چگالی بالاLow-density lipoprotein-cholesterol - کلسترول لیپوپروتئین با چگالی کمWHO - کهGlucose - گلوکز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The disturbances of β-hydroxybutyrate (β-HB) and pyruvate are linked with impaired brain energy utilization which involves in the psychopathology of schizophrenia. This study investigates the difference in levels of β-HB and pyruvate between patients with schizophrenia and healthy controls, and explores their relationship with metabolic profiles and disease characteristics. We recruited 54 physically-health schizophrenic patients and 54 age- and gender-matched healthy control subjects. Blood samples were gathered to determine the serum levels of β-HB and pyruvate and plasma levels of metabolic profiles, including fasting glucose, triglycerides, total cholesterol, high- and low-density lipoprotein-cholesterol and adiponectin. The disease characteristics and psychopathology of patients with schizophrenia were assessed by using the Positive and Negative Syndrome Scale. Of patients with schizophrenia, serum levels of β-HB were significantly correlated with fasting glucose (p = 0.007) and triglycerides (p = 0.021). Pyruvate was significantly correlated with fasting glucose (p = 0.018), total cholesterol (p = 0.005), triglycerides (p = 0.014) and LDL-C (p = 0.006). After controlling the metabolic profiles, β-HB was still significantly higher in schizophrenia patients than in controls (p < 0.001), but no difference in pyruvate was observed. Neither β-HB nor pyruvate was significantly correlated with disease characteristics. However, pyruvate was higher in patients treated with olanzapine or clozapine than in those treated with other antipsychotics (p = 0.048). Findings suggest that schizophrenic patients had significantly higher serum levels of β-HB than control subjects, possibly reflecting higher demands in energy utilization. Serum levels of β-HB, rather than pyruvate, may act as a potential indicator of energy utilization impairment for schizophrenia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychoneuroendocrinology - Volume 73, November 2016, Pages 1-8
Journal: Psychoneuroendocrinology - Volume 73, November 2016, Pages 1-8
نویسندگان
Yu-Chi Huang, Pao-Yen Lin, Yu Lee, Chih-Ching Wu, Su-Ting Hsu, Chi-Fa Hung, Chien-Chih Chen, Mian-Yoon Chong, Chieh-Hsin Lin, Liang-Jen Wang,