کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6817885 | 547102 | 2016 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Juvenile exposure to a high fat diet promotes behavioral and limbic alterations in the absence of obesity
ترجمه فارسی عنوان
قرار گرفتن نوجوانان در رژیم غذایی با چربی بالا باعث تغییرات رفتاری و لنفاوی در غیاب چاقی می شود
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کلمات کلیدی
TNFαNOLSGZIBA1T2DTSTGCLDcxHFDEPMIRSIL1β - IL1bLp-PLA2 - LP-PLA2Tail suspension test - آزمون تعلیق دمinsulin receptor substrate - انسولین بستر گیرندهelevated plus maze - بالا به همراه پیچ و خمAlzheimer’s disease - بیماری آلزایمرtumor necrosis factor α - تومور نکروز عامل αdoublecortin - دوچرخهType 2 diabetes - دیابت نوع 2High fat diet - رژیم غذایی با چربی بالاcontrol diet - رژیم غذایی کنترلNest building - ساختمان لانهdentate gyrus - شکنج دندانه دارEmotionality - عاطفیCognitive performance - عملکرد شناختیLipoprotein-associated phospholipase A2 - فسفولیپاز A2 مرتبط با لیپوپروتئینgranular cell layer - لایه سلولی گرانولHypothalamic-pituitary-adrenal axis - محور هیپوتالاموس-هیپوفیز-آدرنالsubgranular zone - منطقه غده گرانولیionized calcium binding adapter molecule 1 - مولکول آداپتور اتصال دهنده کلسیم یونیزه 1HPA - میلی بار یا هکتوپاسکالNeurogenesis - نوروژنزPeriadolescence - چند ساله
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
چکیده انگلیسی
The incidence of metabolic disorders including obesity, type 2 diabetes and metabolic syndrome have seriously increased in the last decades. These diseases - with growing impact in modern societies - constitute major risk factors for neurodegenerative disorders such as Alzheimer's disease (AD), sharing insulin resistance, inflammation and associated cognitive impairment. However, cerebral cellular and molecular pathways involved are not yet clearly understood. Thus, our aim was to study the impact of a non-severe high fat diet (HFD) that resembles western-like alimentary habits, particularly involving juvenile stages where the brain physiology and connectivity are in plain maturation. To this end, one-month-old C57BL/6J male mice were given either a control diet or HFD during 4 months. Exposure to HFD produced metabolic alterations along with changes in behavioral and central parameters, in the absence of obesity. Two-month-old HFD mice showed increased glycemia and plasmatic IL1β but these values normalized at the end of the HFD protocol at 5 months of age, probably representing an acute response that is compensated at later stages. After four months of HFD exposure, mice presented dyslipidemia, increased Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity, hepatic insulin resistance and inflammation. Alterations in the behavioral profile of the HFD group were shown by the impediment in nest building behavior, deficiencies in short and mid-term spatial memories, anxious and depressive- like behavior. Regarding the latter disruptions in emotional processing, we found an increased neural activity in the amygdala, shown by a greater number of c-Fos+ nuclei. We found that hippocampal adult neurogenesis was decreased in HFD mice, showing diminished cell proliferation measured as Ki67+ cells and neuronal differentiation in SGZ by doublecortin labeling. These phenomena were accompanied by a neuroinflammatory and insulin-resistant state in the hippocampus, depicted by a reactive phenotype in Iba1+ microglia cells (increased in number and soma size) and an impaired response to insulin given by decreased phosphorylated Akt levels and increased levels of inhibitory phosphorylation of IRS1. Our data portray a set of alterations in behavioral and neural parameters as a consequence of an early-life exposure to a quite moderate high fat diet, many of which can resemble AD-related features. These results highly emphasize the need to study how metabolic and neurodegenerative disorders are interrelated in deep, thus allowing the finding of successful preventive and therapeutic approaches.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychoneuroendocrinology - Volume 72, October 2016, Pages 22-33
Journal: Psychoneuroendocrinology - Volume 72, October 2016, Pages 22-33
نویسندگان
Angeles Vinuesa, Carlos Pomilio, Martin Menafra, Maria Marta Bonaventura, Laura Garay, MarÃa Florencia Mercogliano, Roxana Schillaci, Victoria Lux Lantos, Fernando Brites, Juan Beauquis, Flavia Saravia,