کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6819304 | 547098 | 2015 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Rat dams exposed repeatedly to a daily brief separation from the pups exhibit increased maternal behavior, decreased anxiety and altered levels of receptors for estrogens (ERα, ERβ), oxytocin and serotonin (5-HT1A) in their brain
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کلمات کلیدی
serotonin receptor type 1ACA1-3NDSERαERβMPOAS.E.M.EPMBLAPNDNGSHIPPOTRCPUPFC5-HT1ARPBSDABbasolateral amygdala - amygdala basolateralcaudate-putamen - Caudate-PutamenCeA - CEAAmygdala - آمیگدال، بادامهAnxiety - اضطرابelevated plus maze - بالا به همراه پیچ و خمanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceGEE - جیstandard error of the mean - خطای استاندارد میانگینMaternal behavior - رفتار مادریpostnatal day - روز پس از زایمانnormal goat serum - سرم طبیعی بزnormal donkey serum - سرم عسل طبیعیlateral septum - سپتوم جانبیSerotonergic system - سیستم سروتونرژیکdentate gyrus - شکنج دندانه دارOcc - عجبPhosphate buffered saline - فسفات بافر شورOccipital cortex - قشر Occipitalprefrontal cortex - قشر prefrontalSomatosensory cortex - قشر سامهوسنسوریbelow detection limit - محدودیت تشخیص پایینCerebellum - مخچهmedial preoptic area - منطقه پیشوپتیک مدیاNucleus accumbens - هسته accumbenscentral amygdaloid nucleus - هسته مرکزی amygdaloidHippocampus - هیپوکامپ oxytocin receptor - گیرنده اکسی توسینOxytocin receptors - گیرنده های Oxytocinestrogen receptors - گیرنده های استروژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Rat dams exposed repeatedly to a daily brief separation from the pups exhibit increased maternal behavior, decreased anxiety and altered levels of receptors for estrogens (ERα, ERβ), oxytocin and serotonin (5-HT1A) in their brain Rat dams exposed repeatedly to a daily brief separation from the pups exhibit increased maternal behavior, decreased anxiety and altered levels of receptors for estrogens (ERα, ERβ), oxytocin and serotonin (5-HT1A) in their brain](/preview/png/6819304.png)
چکیده انگلیسی
In the present study we investigated the neurobiological mechanisms underlying expression of maternal behavior. Increased maternal behavior was experimentally induced by a brief 15-min separation between the mother and the pups during postnatal days 1 to 22. On postnatal days (PND) 12 and 22, we determined in experimental and control dams levels of anxiety in the elevated plus maze (EPM) as well as the levels of receptors for estrogens (ERα, ERβ), oxytocin (OTR) and serotonin (5-HT1AR) in areas of the limbic system (prefrontal cortex-PFC, hippocampus, lateral septum-SL, medial preoptic area-MPOA, shell of nucleus accumbens-nAc-Sh, central-CeA and basolateral-BLA amygdala), involved in the regulation of maternal behavior. Experimental dams, which showed increased maternal behavior towards their offspring, displayed reduced anxiety in the EPM on both PND12 and PND22. These behavioral differences could be attributed to neurochemical alterations in their brain: On both PND12 and PND22, experimental mothers had higher levels of ERα and OTRs in the PFC, hippocampus, CeA, SL, MPOA and nAc-Sh. The experimental manipulation-induced increase in ERβ levels was less widespread, being localized in PFC, the hippocampal CA2 area, MPOA and nAc-Sh. In addition, 5-HT1ARs were reduced in the PFC, hippocampus, CeA, MPOA and nAc-Sh of the experimental mothers. Our results show that the experience of the daily repeated brief separation from the pups results in increased brain ERs and OTRs, as well as decreased 5-HT1ARs in the dam's brain; these neurochemical changes could underlie the observed increase in maternal behavior and the reduction of anxiety.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychoneuroendocrinology - Volume 52, February 2015, Pages 212-228
Journal: Psychoneuroendocrinology - Volume 52, February 2015, Pages 212-228
نویسندگان
Antonios Stamatakis, Theodora Kalpachidou, Androniki Raftogianni, Efstratia Zografou, Athanasia Tzanou, Stavroula Pondiki, Fotini Stylianopoulou,