کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6824624 548502 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure
چکیده انگلیسی
Single nucleotide polymorphisms (SNPs) within the MIR137, TCF4, and ZNF804A genes show genome-wide association to schizophrenia. However, the biological basis for the associations is unknown. Here, we tested the effects of these genes on brain structure in 1300 healthy adults. Using volumetry and voxel-based morphometry, neither gene-wide effects-including the combined effect of the genes-nor single SNP effects-including specific psychosis risk SNPs-were found on total brain volume, grey matter, white matter, or hippocampal volume. These results suggest that the associations between these risk genes and schizophrenia are unlikely to be mediated via effects on macroscopic brain structure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 159, Issues 2–3, November 2014, Pages 329-332
نویسندگان
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