Regioselective nucleophilic opening of epoxides and aziridines under neutral conditions in the presence of β-cyclodextrin in water

A variety of β-hydroxy nitriles and β-amino alcohols have been synthesized by the regioselective ring opening of epoxides and aziridines under neutral and aqueous conditions in the presence of β-cyclodextrin in good yields.

Various of β-hydroxy nitriles and β-amino alcohols have been synthesized regioselectively from epoxides and N-tosyl aziridines in the presence of β-cyclodextrin in good yields. Figure optionsDownload as PowerPoint slide