Molecular shape selectivity of hydrotalcite in mixed aldol condensations of aldehydes and ketones

The work has engaged in the effect of activated hydrotalcite for aldol condensation of cyclic and linear ketones with n-heptanal and norborn-5-ene-2-carbaldehyde. A significant configuration selectivity of the catalyst was found, when the condensation of the cyclic ketones was strongly prefered in comparison with condensation of the linear ones. The mechanism of the surface reaction was predicted by the methods of molecular modeling.

The work has engaged in the effect of activated hydrotalcite for aldol condensation of cyclic and linear ketones with n-heptanal and norborn-5-ene-2-carbaldehyde. It was found a significant configuration selectivity of the catalyst, the condensation of the cyclic ketones was strongly preferred compare to the linear one. The mechanism of the surface reaction was predicted by the methods of molecular modeling. Figure optionsDownload as PowerPoint slide