کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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68521 | 48516 | 2008 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The synthesis of silica-supported chiral BINOL: Application in Ti-catalyzed asymmetric addition of diethylzinc to aldehydes The synthesis of silica-supported chiral BINOL: Application in Ti-catalyzed asymmetric addition of diethylzinc to aldehydes](/preview/png/68521.png)
Chiral BINOL was covalently anchored on two different pore sized mesoporous silica (SBA-15 (7.5 nm) and MCF (14 nm)). These heterogenized ligands were used in Ti-catalyzed asymmetric addition of diethylzinc to aldehydes. High catalytic activity with excellent enantioselectivity (up to 94% ee) for secondary alcohols was achieved using MCF supported chiral BINOL under heterogeneous reaction conditions. Good to excellent enantioselectivity (ee, 68–91%) was also achieved with various small to bulkier aldehydes. The MCF supported catalyst was reused in multiple catalytic runs without loss of enantioselectivity.
Silica-supported chiral BINOL was synthesized on two different pore sized mesoporous silica (SBA-15 (7.5 nm) and MCF (14 nm)), and shown to be highly active with an excellent enantioselectivity (up to 94% ee) in Ti-catalyzed asymmetric addition of diethylzinc to aldehydes. The MCF supported catalyst was reused in multiple catalytic runs without loss of enantioselectivity.Figure optionsDownload as PowerPoint slide
Journal: Journal of Molecular Catalysis A: Chemical - Volume 280, Issues 1–2, 4 February 2008, Pages 106–114