کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6856773 | 1437970 | 2018 | 39 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Optimization of combination chemotherapy with dose adjustment using a memetic algorithm
ترجمه فارسی عنوان
بهینه سازی شیمی درمانی ترکیبی با تنظیم دوز با استفاده از الگوریتم مامتیک
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی کامپیوتر
هوش مصنوعی
چکیده انگلیسی
The problem with optimizing cancer chemotherapy has often been formulated as optimal control models, which can be intractable. Such difficulty is compounded by the facts that chemotherapeutic drugs with different mechanisms of action are often used together and that dose adjustments are often warranted according to therapeutic responses in clinical practice. Against this background, this paper addresses the problem of combination chemotherapy with dose adjustment. We first construct a mathematical model of the problem by introducing two cell-cycle phase-specific chemotherapeutic drugs into a mono-chemotherapy model. Next, we design a memetic algorithm (MA) allowing dose adjustments to solve the problem. Finally, we compare the proposed MA with existing algorithms, investigate the efficacies of different treatment strategies, and identify the characteristics of the problem related to the quality of the solutions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Information Sciences - Volume 432, March 2018, Pages 63-78
Journal: Information Sciences - Volume 432, March 2018, Pages 63-78
نویسندگان
Peilian Wang, Ran Liu, Zhibin Jiang,