A recyclable multi-substrates catalytic system for enantioselective reduction of ketones in water

Enantioselective reductions of a variety of aromatic ketones catalyzed by [RuCl2(p-cymene)]2 coordinated by N-phenyl-(l)-proline amide in water have been performed with high asymmetric inductions in several cases. The reusability of catalyst has been studied. A multi-substrate recycling of the catalyst afforded successively seven alcohols each with similar enantiomeric excess than the one recorded in a single run.

Enantioselective reductions of a variety of aromatic ketones have been performed with high asymmetric inductions in several cases. A multi-substrate recycling of the catalyst afforded successively seven alcohols each with similar enantiomeric excess than the one recorded in a single run. Figure optionsDownload as PowerPoint slide