Structure based virtual screening to identify selective phosphodiesterase 4B inhibitors

- Ligand based pharmacophore models were developed for PDE4B and PDE4D inhibitors.
- The developed pharmacophore model was validated by multiple approaches.
- Three different databases were screened by means of validated pharmacophore models.
- Docking analysis provided an insight into selective PDE4B inhibition.
- The results were confirmed by the in vitro evaluation of screened hits.