Aqueous phase synthesis of vic-halohydrins from olefins and N-halosuccinimides in the presence of β-cyclodextrin

A series of bromo- and iodohydrins was prepared regioselectively in excellent yields in one-step procedure by treating the corresponding alkenes at room temperature with NBS and NIS respectively in the presence of β-cyclodextrin in water.

Various vic-halohydrins have been synthesized with N-halosuccinimides from olefins in the presence of β-cyclodextrin in water. Figure optionsDownload as PowerPoint slide