کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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69095 | 48530 | 2006 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: (S)-2-Aryl-4,4-diphenyl-3,1,2-oxazaboro[3.3.0]octanes: Efficient catalysts for the asymmetric borane reduction of electron-deficient ketones (S)-2-Aryl-4,4-diphenyl-3,1,2-oxazaboro[3.3.0]octanes: Efficient catalysts for the asymmetric borane reduction of electron-deficient ketones](/preview/png/69095.png)
The obvious influence of electronic effects of ketones on the enantioselectivities was observed previously in the oxazaborolidine-catalyzed asymmetric borane reduction of ketones. On the basis of the catalytic reduction mechanism, the electronic effect of organocatalysts, B-aryl-substituted oxazaborolidines, was tuned rationally to improve the enantioselectivities of the electron-deficient ketones in the reduction. The results indicate that all B-aryloxazaborolidines show excellent enantioselectivities for the electron-deficient ketones. This indicates that B-aryloxazaborolidines show better enantioselectivities than B-unsubstituted and B-methoxy-substituted oxazaborolidines for the electron-deficient ketones.
B-aryl-substituted oxazaborolidines were tuned rationally to improve the enantioselectivities of the electron-deficient ketones in the reduction. The results indicate that all B-aryloxazaborolidines show excellent enantioselectivities for the electron-deficient ketones. Figure optionsDownload as PowerPoint slide
Journal: Journal of Molecular Catalysis A: Chemical - Volume 244, Issues 1–2, 1 February 2006, Pages 68–72