کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6956853 1451894 2018 34 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Towards optimized naphthalocyanines as sonochromes for photoacoustic imaging in vivo
موضوعات مرتبط
مهندسی و علوم پایه شیمی طیف سنجی
پیش نمایش صفحه اول مقاله
Towards optimized naphthalocyanines as sonochromes for photoacoustic imaging in vivo
چکیده انگلیسی
In this paper we establish a methodology to predict photoacoustic imaging capabilities from the structure of absorber molecules (sonochromes). The comparative in vitro and in vivo screening of naphthalocyanines and cyanine dyes has shown a substitution pattern dependent shift in photoacoustic excitation wavelength, with distal substitution producing the preferred maximum around 800 nm. Central ion change showed variable production of photoacoustic signals, as well as singlet oxygen photoproduction and fluorescence with the optimum for photoacoustic imaging being nickel(II). Our approach paves the way for the design, evaluation and realization of optimized sonochromes as photoacoustic contrast agents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Photoacoustics - Volume 9, March 2018, Pages 49-61
نویسندگان
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