کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6969563 | 1453040 | 2016 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chlorination by-products of bisphenol A enhanced retinoid X receptor disrupting effects
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
BPA9cRAERRγNaClOICCRXRDBPsRetinoid X receptorTEQChlorinated byproducts2,4,6-Trichlorophenol - 2،4،6-تری کلروفنولEDCs - EDC هاGC/MS - GC / MSBisphenol A - بیسفنول ای، بیسفنول ASodium hypochlorite - سدیم هیپوکلریتDisinfection byproducts - ضایعات ضدعفونی کنندهTCP - قرارداد هدایت انتقالEndocrine-disrupting chemicals - مواد شیمیایی خرابکار غدد درون ریزMolecular docking - پیوندهای بین مولکولیgas chromatography/mass spectrometry - کروماتوگرافی گاز / طیف سنج جرمیEstrogen receptor - گیرنده استروژنThyroid receptor - گیرنده تیروئید
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بهداشت و امنیت شیمی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
There is increasing evidence of activities of chlorinated by-products of bisphenol A (BPA) on retinoic acid system. Their agonistic and antagonistic activities to human retinoid X receptor (RXR) were assessed by a two-hybrid yeast assay. Aqueous solutions of 1 mg/L BPA were chlorinated by sodium hypochlorite (NaClO). It showed that chlorination of BPA increased RXRβ antagonistic activity, while no agonistic activity was detected, showing chlorine might act as a toxic potentiator rather than a toxic deactivator in RXRβ disrupting effects. BPA and its byproducts including 2,2â²,6,6â²-tetrachlorobisphenol A (TCBPA) and 2,4,6-trichlorophenol (TCP) were quantitatively determined by gas chromatography/mass spectrometry (GC/MS). BPA rapidly degraded. With the increasing of ICC and reaction time, concentration of formed TCBPA increased initially then decreased, while concentration of formed TCP increased stably. Using the toxic equivalent (TEQ) approach, the main contributors should be mono-, di- and tri- chlorobisphenol A at initial chlorine concentration (ICC) of 1 mg/L. At ICC of 2 and 5 mg/L, the main contributors were TCBPA and TCP, being 57.7%-70.7% and 45.3%-59.4%. Molecular docking showed BPA chlorination by-products might have the same mode of action with BPA, forming hydrogen bond and pi-pi interaction with their OH group or hydrophobic ring.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hazardous Materials - Volume 320, 15 December 2016, Pages 289-295
Journal: Journal of Hazardous Materials - Volume 320, 15 December 2016, Pages 289-295
نویسندگان
Na Li, Weiwei Jiang, Mei Ma, Donghong Wang, Zijian Wang,