کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6972301 | 1453098 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Size fraction effect on phthalate esters accumulation, bioaccessibility and in vitro cytotoxicity of indoor/outdoor dust, and risk assessment of human exposure
ترجمه فارسی عنوان
اثر کسر اندازه بر تجمع استات اکسید آهن، دسترسی به زیست محیطی و در معرض سیتوتوکسی سولفوریک گرد و غبار داخلی / فضای باز و ارزیابی خطر قرار گرفتن در معرض قرار گرفتن در معرض انسانی
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کلمات کلیدی
استرها فتالات اثر کسر اندازه، سمیت مسمومیت، دسترسی بیواسطه، ارزیابی ریسک، گرد و خاک،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بهداشت و امنیت شیمی
چکیده انگلیسی
Indoor and outdoor dusts from two urban centers in the Pearl River Delta, China, were analyzed and phthalate esters varied from 4.95 to 2220 μg gâ1 in indoor dust, significantly higher than outdoor dust (1.70-869 μg gâ1). Di-2-ethylhexyl phthalate (DEHP) was the dominant phthalate found and the highest distribution factor (DF) (1.56 ± 0.41) was noted in the <63 μm fraction (p < 0.05). In vitro cytotoxicity of dust extract on human T cell lymphoblast leukemic cell line (CCRF-CEM) indicated by Lethal Concentration 50 (LC50) decreased with particle size. The power model was found as a better fit for explaining the relationship between LC50 and phthalates (R2 = 0.46, p < 0.01). Bioaccessibility of phthalates in dust varied with different particle sizes, with the greatest bioaccessible fraction (2.49-38.6%) obtained in <63 μm. Risk assessment indicated that indoor dust ingestion accounted for the major source for DEHP exposure (81.4-96.4% of non-dietary exposure and 36.5% of total exposure), especially for toddlers. The cancer risks associated with DEHP via home dust were high (10â6-10â4), with 10% of houses estimated with unacceptable risks (>10â4). After corrected with the bioaccessibility of phthalates, the cancer risks of dust exposure were moderate (10â7-10â5).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hazardous Materials - Volume 261, 15 October 2013, Pages 753-762
Journal: Journal of Hazardous Materials - Volume 261, 15 October 2013, Pages 753-762
نویسندگان
Wei Wang, Fu-Yong Wu, Min-Juan Huang, Yuan Kang, Kwai Chung Cheung, Ming Hung Wong,