کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
6978114 1453837 2018 10 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Intravenous human serum albumin (HSA)-bound artemether nanoparticles for treatment of severe malaria
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موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
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Intravenous human serum albumin (HSA)-bound artemether nanoparticles for treatment of severe malaria
چکیده انگلیسی
Severe malaria is potentially life-threatening and requires the parenteral administration of the artemisinin-based formulation for short duration of action. Intravenous artemether formulation has shown potentially better therapeutic efficacy but its poor aqueous dissolution constitutes a challenge. This work produced human serum albumin (HSA)-bound artemether nanoparticles by emulsification and desolvation approach using nanoparticle albumin bound (nab) technology for intravenous (IV) administration. The prepared nanoparticles had a size below 50 nm. It was observed that higher HSA concentration; lower drug concentration and longer ultrasonication time (up to 60 s) favoured the production of smaller particles. Comparatively, the emulsification method allowed for higher drug entrapment per the same concentration of HSA and required less organic solvent, less water and less energy and is therefore the preferred method. HSA-bound artemether nanoparticles displayed significantly enhanced dissolution properties over raw artemether. In-vitro haemolysis studies demonstrated a significant decrease in haemolysis caused by artemether from 101% to 7% in the emulsification product and to 4% by the desolvation product.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Volume 536, 5 January 2018, Pages 20-29
نویسندگان
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