Rhodamine-loaded, cross-linked, carboxymethyl cellulose sodium-coated super-paramagnetic iron oxide nanoparticles: Development and in vitro localization study for magnetic drug-targeting applications

- Various capping agents were screened to formulate small-sized, stable SPIONs.
- SPIONs were optimized using crosslinked-CMC as capping agent around iron oxide cores.
- TEM showed core-shell structure and FTIR confirmed interaction of CMC with iron oxide.
- Decent saturation magnetization due to iron oxide phase depicted by VSM and XRD.
- In vitro localization in microcapillary indicated a biconvex localization pattern.