Solid lipid nanoparticles (SLN) stabilized with polyhydroxy surfactants: Preparation, characterization and physical stability investigation

- Polyhydroxy surfactants are suitable surfactants for the stabilization of SLN.
- Their use leads to small sized and physically stable SLN.
- Their use enables the production of “skin-friendly” SLN for dermal drug delivery.
- Physico-chemical properties of surfactants strongly influence size/stability of SLN.
- Alkyl chain lengths of lipid matrix of SLN and stabilizer should be similar.