Influence of the preparation method on the physicochemical properties of econazole-loaded poly(butyl cyanoacrylate) colloidal nanoparticles

► Econazole-loaded poly(butyl cyanoacrylate) nanoparticles are prepared by different methods. ► The nanoparticle size and drug content depend on the preparation method. ► The type of colloidal stabilizer affected the values of ζ-potentials. ► The nanoprecipitation method resulted in the formation of more stable nanoparticles.