Sulfisoxazole/cyclodextrin inclusion complex incorporated in electrospun hydroxypropyl cellulose nanofibers as drug delivery system

- Sulfisoxazole(SFS) or SFS/HPβCD-IC was incorporated into HPC NF by electrospinning.
- The stoichiometry of SFS/HPβCD-IC was determined as 1:1 by Job's plot and modeling.
- SFS/HPβCD-IC distributed in amorphous state as shown in XRD and DSC results.
- Solubility of SFS was increased by inclusion complexation with HPβCD.
- Higher amount of SFS was released from HPC/SFS/HPβCD-IC NF than HPC/SFS NF.