On the correlation between the structure of lyotropic carriers and the delivery profiles of two common NSAIDs

- Cubic and lamellar mesophases were characterized as transdermal drug delivery vehicles.
- Sodium diclofenac stabilizes, while celecoxib disturbs, the nanostructure self-assembly.
- The cubic system releases 1.5-fold higher amounts of sodium diclofenac than the lamellar.
- Celecoxib release is not affected from the water content; the drugs diffuse differently.
- The diffusion kinetics might be controlled by manipulating the mesophase composition.