Drug release mechanisms of chemically cross-linked albumin microparticles: Effect of the matrix erosion

- Albumin (BSA) microparticles were obtained in a W/O emulsion without and with PVA.
- BSA played a role as a surface active agent for W/O emulsion, replacing PVA.
- The microparticles showed a two-stage drug release profile at pH 2, 6 and 10.
- The two-step release mechanism is a characteristic of the BSA microparticles.
- The second release stage is a contribution of the matrix erosion.