Structure-activity relationship of carbamate-linked cationic lipids bearing hydroxyethyl headgroup for gene delivery

- Three new carbamate-linked cationic lipids with hydroxyl headgroup were synthesized.
- These lipids are easy to produce starting from environmentally friendly materials.
- These liposomes exhibit relatively high transfection efficiency and low toxicity.
- The inclusion of hydroxyl group in the headgroup can improve transfection efficiency.