کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
701058 1460815 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diamond nano-wires, a new approach towards next generation electrochemical gene sensor platforms
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی برق و الکترونیک
پیش نمایش صفحه اول مقاله
Diamond nano-wires, a new approach towards next generation electrochemical gene sensor platforms
چکیده انگلیسی

A novel bio-sensing platform is introduced by combination of a) geometrically controlled DNA bonding using vertically aligned diamond nano-wires and b) the superior electrochemical sensing properties of diamond as transducer material. Ultra-hard vertically aligned diamond nano-wires are electrochemically modified to bond phenyl linker-molecules to their tips which provide mesospacing for DNA molecules on the transducer. The nano-wires are generated by reactive ion etching of metallically boron doped atomically smooth single crystalline CVD diamond. Surface properties are characterized by atomic force, scanning electron and scanning tunneling microcopy. Electro- and bio-chemical sensor properties are investigated using cyclic and differential pulse voltammetry as well as impedance spectroscopy with Fe(CN)63-/4- as redox mediators which reveal sensitivities of 2 pM on 3 mm2 sensor areas and superior DNA bonding stability over 30 hybridization/denaturation cycles. The fabrication of “all diamond” ultra-micro-electrode (UME) arrays and multi-gene sensors are discussed taking into account the unique properties of diamond.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diamond and Related Materials - Volume 18, Issues 5–8, May–August 2009, Pages 910–917
نویسندگان
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