Enhancement of catechin skin permeation via a newly fabricated mPEG-PCL-graft-2-hydroxycellulose membrane

► Green tea catechins are known to have medicinal anti-inflammatory and antioxidative functions. ► Orally administrated catechins are metabolized in body, leading to low bioavailability. ► This paper presents in vitro and in vivo permeation of catechins through the skin. ► Catechin-loaded cellulose membrane grafted with PEG-PCL shows increased bioavailability. ► The amphiphilic PEG-PCL can modify the permeation flux of cellulose membrane for catechins.