کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7076590 1459976 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Co-metabolic oxidation of pharmaceutical compounds by a nitrifying bacterial enrichment
ترجمه فارسی عنوان
اکسیداسیون ترکیبات متابولیک از ترکیبات دارویی با غنی سازی باکتری نیتروژن
کلمات کلیدی
تجزیه زیستی داروها، متابولیسم مشترک، باکتری اکسید کننده آمونیاک، آمونیاک مونوکسینژاز،
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی تکنولوژی و شیمی فرآیندی
چکیده انگلیسی
The biotransformation of five selected pharmaceuticals ibuprofen (IBP), ketoprofen (KTP), carbamazepine (CBZ), dexamethasone (DXM) and iopromide (IOP) by a stable nitrifying enrichment culture was investigated at concentrations ranging between 25 μg/L and 2 mg/L. Complete biotransformation was observed only for IBP and KTP, although, an inverse correlation between transformation rate and concentration was found. The transformation pattern observed is consistent with ammonia monooxygenase (AMO) activity. The metabolic succession of the compounds according to the biotransformation rates was: IBP > KTP > DXM > CBZ > IOP. A linear correlation between the calculated diffusive flux of the model compounds across a bilayer membrane and their biotransformation rates was found. Our results support the concept that augmentation with nitrifying activity can enhance the removal of trace organic pollutants during effluent treatment. Furthermore, ammonia-oxidizing activity appears as a good indicator for estimation of potential of biodegradability of pharmaceuticals, especially at low concentrations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioresource Technology - Volume 167, September 2014, Pages 336-342
نویسندگان
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