Ethanol-based organosolv fractionation of wheat straw for the production of lignin and enzymatically digestible cellulose

► Wheat straw biorefining by ethanol organosolv into lignin and digestible cellulose. ► Major optimization parameters: temperature, ethanol concentration, and acid dose. ► Biomass particle size and reaction time less influential process parameters. ► Optimum enzymatic glucose yield of 86% after autocatalytic organosolv. ► High yields of lignin, furfural, and sugars by acid-catalysed organosolv.