کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7138942 1462017 2018 28 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A self-assembled micellar nanoprobe for specific recognition of hydrazine in vitro and in vivo
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
A self-assembled micellar nanoprobe for specific recognition of hydrazine in vitro and in vivo
چکیده انگلیسی
Hydrazine is a probable human carcinogen and exhibits critical damage to living system. Developing an effective method to detect hydrazine in living samples holds great potential for cancer diagnosis, treatment, and management. In this work, we first fabricate a self-assembled micellar nanoprobe for specific recognition of hydrazine in vitro and in vivo in aqueous solution. The novel probe (T-M) contains a triphenylamine fluorophore as a reporter and malononitrile group as the triggered moiety, then we encapsulated T-M into the hydrophobic interior of an amphiphilic copolymer (mPEG-DSPE) and prepared a novel self-assembled micellar nanoprobe: NanoT-M. The nanoprobe exhibits ultra-sensitivity, high selectivity and good biocompatibility. Furthermore, the nanoprobe shows favourable cellular uptaken and was successfully used to detect intracellular hydrazine in living cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 272, 1 November 2018, Pages 479-484
نویسندگان
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