کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7229272 | 1470920 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Flexible multichannel vagus nerve electrode for stimulation and recording for heart failure treatment
ترجمه فارسی عنوان
الکترودهای عصبی چندگانه انعطاف پذیر برای تحریک و ضبط برای درمان نارسایی قلبی
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کلمات کلیدی
عصب واگ، الکترود کاف، تحریک ضبط چند کانال، طیف سنجی امپدانس الکتروشیمیایی، ولتامتری سیسیک،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Vagus nerve stimulation is an emerging bioelectronic medicine to modulate cardiac function, as the nerve provides parasympathetic innervation to the heart. In this study, we developed a polyimide based 2D cuff electrode to wrap around on the vagus nerve. Thanks to the tiny size and bendable protruding structure of the contact tips of the device, the electrode sites are able to flexibly bend to touch the nerve, selectively record and stimulate the vagus nerve. Gold, platinum and platinum black materials were chosen to compose the electrodes for nerve stimulation and recording, respectively. Since the platinum black has ~30 times larger charge delivery capacity (CDC) than gold, Pt black electrode is used for nerve stimulation. The electrochemical impedance spectroscopy and cyclic voltammetry measurement of the three materials were conducted in vitro, revealing the results of 405â¯kΩ, 41â¯kΩ, 10.5â¯kΩ, @1â¯kHz and 0.81â¯mC/cm2, 4.26â¯mC/cm2, 25.5â¯mC/cm2, respectively (nâ¯=â¯3). The cuff electrodes were implanted into the right-sided vagus nerve of rats for in vivo experiment. Biphasic current configuration was implemented for nerve stimulation with frequency of 10â¯Hz, pulse during of 300â¯Î¼s and various currents stimulus. The result shows the heart beat frequency drops up to 36% during the stimulation and was able to return the regular frequency as stimulation was removed. Subsequently, the vagus nerve signals were recorded with the four channel cuff electrodes. The magnitude of the compound nerve action potentials (CNAPs) is ~10â¯Î¼V and the signal to noise ratio (SNR) is ~20.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 112, 30 July 2018, Pages 114-119
Journal: Biosensors and Bioelectronics - Volume 112, 30 July 2018, Pages 114-119
نویسندگان
Ning Xue, Ignacio Delgado Martinez, Jianhai Sun, Yuhua Cheng, Chunxiu Liu,