کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7232568 | 1644974 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cyclodextrin functionalized graphene-gold nanoparticle hybrids with strong supramolecular capability for electrochemical thrombin aptasensor
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cyclodextrin functionalized graphene-gold nanoparticle hybrids with strong supramolecular capability for electrochemical thrombin aptasensor Cyclodextrin functionalized graphene-gold nanoparticle hybrids with strong supramolecular capability for electrochemical thrombin aptasensor](/preview/png/7232568.png)
چکیده انگلیسی
We demonstrate a facile one-pot synthetic strategy for controlled synthesis of thio-β-cyclodextrin functionalized graphene/gold nanoparticles (SH-β-CD-Gr/AuNPs) composites using SH-β-CD as both the dispersant and linker. The obtained SH-β-CD-Gr/AuNPs integrate the excellent electrical properties and large surface area of graphene and AuNPs with supramolecular recognition ability of CD, which show more effective electron transfer and higher enriched ability for the ferrocene probe via the host-guest interaction between CD and ferrocene than SH-β-CD-Gr. In the presence of target, the stronger interaction between aptamer and target makes the ferrocene move closer to the electrode surface, thus facilitating the electron transfer. Based on this sensing mechanism, a new and highly sensitive biosensing concept by the use of SH-β-CD-Gr/AuNPs as enhancing materials is demonstrated for “signal-on” detection of targets (thrombin as a model target). This biosensor exhibits a wide linear range for thrombin from 1.6Ã10â17 M to 8.0Ã10â15 M and a very low limit of detection 5.2Ã10â18 M, which is two-order magnitude better than those of SH-β-CD-Gr (the detection linear range from 1.6Ã10â15 M to 8.0Ã10â13 M and detection limit of 1.0Ã10â15 M). Our proposed electrochemical aptasensor based on SH-β-CD-Gr/AuNPs shows good selectivity against other proteins such as human serum albumin, lysozyme and insulin. To the best of our knowledge, the present SH-β-CD-Gr/AuNPs hybrids are the most efficient graphene-based electrochemical active probes ever reported for biosensors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 68, 15 June 2015, Pages 429-436
Journal: Biosensors and Bioelectronics - Volume 68, 15 June 2015, Pages 429-436
نویسندگان
Qiong Xue, Zhiguang Liu, Yujing Guo, Shaojun Guo,