An efficient fluorescent sensing platform for biomolecules based on fenton reaction triggered molecular beacon cleavage strategy

► A universal sensing platform for fluorescence detection of biomolecules is developed. ► The proposed sensing system is based on a Fenton reaction triggered molecular beacon cleavage strategy. ► It shows a “turn-on” fluorescence response to target biomolecule with high sensitivity. ► It also exhibits high selectivity owing to the high specificity of the enzymatic oxidation.