Gold nanoparticles in injectable calcium phosphate cement enhance osteogenic differentiation of human dental pulp stem cells

Calcium phosphate cement (CPC) is an injectable scaffold with promising applications in dental and plastic surgeries. Here, we improved CPC by incorporation of a gold nanoparticles (GNPs) solution. GNP-CPC significantly enhanced the osteogenic functions of seeded human dental stem cells. The effects were attributed to the micro-nano-structure of GNP-CPC and the cells' internalization of GNPs released from GNP-CPC. Therefore, GNPs are promising for use in bone tissue engineering, and modifying CPC with nanotechnology can enhance bone regeneration.428