Complexes of N,N-bis (salicylidene)4,5-dimethyl-1,2-phenylenediamine immobilized on porous nanomaterials: Synthesis, characterization and study of their antimicrobial activity

• Transition metal complexes of tetradentate Schiff base ligand immobilized on porous material.
• Hybrid materials show good crystallinity.
• The in vitro antibacterial activity of these hybrid materials was evaluated.
• The hybrid materials exhibit high bactericidal activities.

A new hybrid antibacterial material was developed by post synthesis grafting method. 3-aminopropyl triethoxysilane (3-APTES) was first anchored over MCM-41 and NaY Zeolite upon reaction with transition metal (M = Mn(II), Co(II) and Cu(II)) complexes of tetradentate Schiff base ligand L: (C22H20N2O2). The prepared materials were characterized by several techniques: chemical analysis, diffuse reflectance spectroscopy (DRS), Fourier transfer infrared (FT-IR), X-ray diffraction (XRD), thermogravimetric analysis (TGA) and Burner–Emmet–Taller(BET). The in vitro antibacterial activity of these compounds was evaluated against Staphylococcus aureus (S. aureus) and Bacillus subtilis (B. subtilis), as Gram-positive bacteria, and further against Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa), as Gram-negative bacteria. Then, the results were compared with standard drugs. The analysis revealed that hybrid materials that prepared by immobilization Schiff base in porous materials show fine inhibition on bacterial growth till 24 h.

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