Controlled size synthesis and application of nanosphere MCM-41 as potent adsorber of drugs: A novel approach to new antidote agent for intoxication

• Nanosphere sized MSNs containing functional groups were prepared and characterized.
• Synthesized MSNs dispersed well in aqueous solution without precipitation.
• Novel application of synthesized MSNs as potent drug adsorbers was suggested.
• Efficiency of synthesized MSNs as adsorbers was tested in vitro.
• The adsorption isotherms were established and fitting parameters were calculated.

By using a co-condensation method, mesoporous silica nanoparticles (MSNs) of three different varieties with a MCM-41 pattern of structures containing functional groups inside the pores were prepared. The synthetic structure resulted in formation of highly dispersed MSNs without precipitation. The surface areas along with the pore size distribution were examined using nitrogen adsorption and desorption studies. The synthetic strategy resulted in MCM-41 with surface area greater than 800 (m2/g) and spherical size lower than 50 (nm). The MCM-41 structure and functionality were characterized. The organic layer's quantity was determined. Novel application of synthesized MSNs as potent drug adsorbers was suggested as an alternative to activated charcoal (AC), a traditional detoxifier. The efficiency of these materials as adsorbers was tested in vitro for paracetamol and phenobarbital. The adsorption isotherms were established and fitting parameters were calculated with three isotherm models (i.e., Redlich–Peterson, Freundlich and Langmuir). Finally, the higher loading capacity of established MSNs in comparison with AC was observed.

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