کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7295033 | 1474393 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Event-related oscillations (ERO) during an active discrimination task: Effects of lesions of the nucleus basalis magnocellularis
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کلمات کلیدی
phase locking indexROIEROnucleus basalis magnocellularisNBMACh - آهAcetylcholine - استیل کولینElectroencephalogram - الکتروانسفالوگرافیERP - برنامه ریزی منابع سازمانPLI - بیشترAlzheimer's disease - بیماری آلزایمرanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceCholinergic system - سیستم Cholinergicfrontal cortex - قشر جلوییregion of interest - منطقه مورد نظرEEG - نوار مغزیevent-related oscillations - نوسانات مربوط به رویدادEvent related oscillations - نوسانات مربوط به رویدادEvent-related potentials - پتانسیل مربوط به رویداد یا ERP ChAT - چتcholine acetyltransferase - کولین استیل ترانسفراز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
The cholinergic system in the brain is involved in attentional processes that are engaged for the identification and selection of relevant information in the environment and the formation of new stimulus associations. In the present study we determined the effects of cholinergic lesions of nucleus basalis magnocellularis (NBM) on amplitude and phase characteristics of event related oscillations (EROs) generated in an auditory active discrimination task in rats. Rats were trained to press a lever to begin a series of 1Â kHz tones and to release the lever upon hearing a 2Â kHz tone. A time-frequency based representation was used to determine ERO energy and phase synchronization (phase lock index, PLI) across trials, recorded within frontal cortical structures. Lesions in NBM produced by an infusion of a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) resulted in (1) a reduction of the number of correct behavioral responses in the active discrimination task, (2) an increase in ERO energy in the delta frequency bands, (3) an increase in theta, alpha and beta ERO energy in the N1, P3a and P3b regions of interest (ROI), and (4) an increase in PLI in the theta frequency band in the N1 ROIs. These studies suggest that the NBM cholinergic system is involved in maintaining the synchronization/phase resetting of oscillations in different frequencies in response to the presentation of the target stimuli in an active discrimination task.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Psychophysiology - Volume 103, May 2016, Pages 53-61
Journal: International Journal of Psychophysiology - Volume 103, May 2016, Pages 53-61
نویسندگان
Manuel Sanchez-Alavez, Cindy L. Ehlers,