کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7299054 | 1475142 | 2016 | 41 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Reconsolidation-induced memory persistence: Participation of late phase hippocampal ERK activation
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کلمات کلیدی
dHIPPD098059USHLFSNF-κBHFSLTMERK/MAPK - ERK / MAPKPhosphorylated ERK - ERK فسفریلیت شدهinhibitory avoidance - اجتناب مهار کنندهSDS-PAGE - الکتروفورز ژل پلی آکریل آمیدMemory reconsolidation - تجمع حافظهlong-term memory - حافظه بلندمدتHIP - مفصل ران یا مفصل هیپMice - موشHippocampus - هیپوکامپ dorsal hippocampus - هیپوکامپ پشتیveh - وایInhibitory avoidance task - وظیفه اجتناب از مهارMemory persistence - پایداری حافظهPERK - پرک
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Persistence is an attribute of long-term memories (LTM) that has recently caught researcher's attention in search for mechanisms triggered by experience that assure memory perdurability. Up-to-date, scarce evidence of relationship between reconsolidation and persistence has been described. Here, we characterized hippocampal ERK participation in LTM reconsolidation and persistence using an inhibitory avoidance task (IA) at different time points. Intra-dorsal-hippocampal (dHIP) administration of an ERK inhibitor (PD098059, PD, 1.0 μg/hippocampus) 3 h after retrieval did not affect reconsolidation of a strong IA, when tested 24 h apart. However, the same manipulation impaired performance when animals were tested at 7 d, regardless of the training's strength; and being specific to memory reactivation. To the best of our knowledge, this is the first report showing that persistence might be triggered after memory reactivation involving an ERK/MAPK-dependent process.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Learning and Memory - Volume 133, September 2016, Pages 79-88
Journal: Neurobiology of Learning and Memory - Volume 133, September 2016, Pages 79-88
نویسندگان
M.C. Krawczyk, N. Navarro, M.G. Blake, A. Romano, M. Feld, M.M. Boccia,