کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7300202 | 1475164 | 2014 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protein kinase C mediates memory consolidation of taste avoidance conditioning in Lymnaea stagnalis
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کلمات کلیدی
CREBLTMpKaPKCITMMAPK - MAPKBryostatin - بیواستاتینanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancelong-term memory - حافظه بلندمدتconditioned stimulus - محرک شرطیcyclic AMP response element binding protein - پروتئین اتصال دهنده عنصر پاسخ Cyclic AMPprotein kinase A - پروتئین کیناز AProtein kinase C - پروتئین کیناز سیmitogen-activated protein kinase - پروتئین کیناز فعال با mitogen
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
In Lymnaea stagnalis, in order to obtain a 10 min short-term memory (STM) of taste avoidance conditioning (TAC) at least 10 paired presentations of a conditioned stimulus (CS), sucrose, and an unconditioned stimulus (US), tactile stimulation to the animal's head, are required. Pre-exposure of snails to the protein kinase C (PKC) α and ε activator bryostatin (Bryo) facilitated STM formation in that only 5 paired CS-US trials were required. Typically 20 paired presentations of the CS-US are required for formation of STM and LTM. However, 20 paired presentations do not result in STM or LTM if snails are pre-incubated with a PKC inhibitor, Ro-32-0432. We also found that LTM lasting longer than 48 h was acquired with Bryo incubation for 45 min even after termination of the conditioning paradigm. These data suggest that activation of the α and ε isozymes of PKC is crucially involved in the formation of LTM and provide further support for a mechanism that has been conserved across the evolution of species ranging from invertebrate molluscs to higher mammals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Learning and Memory - Volume 111, May 2014, Pages 9-18
Journal: Neurobiology of Learning and Memory - Volume 111, May 2014, Pages 9-18
نویسندگان
Satoshi Takigami, Hiroshi Sunada, Ken Lukowiak, Alan M. Kuzirian, Daniel L. Alkon, Manabu Sakakibara,