کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7301780 | 1475281 | 2018 | 37 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cerebral small vessel disease and risk of incident stroke, dementia and depression, and all-cause mortality: A systematic review and meta-analysis
ترجمه فارسی عنوان
بیماری عروق کرونر کوچک و خطر سکته مغزی، دمانس و افسردگی، و مرگ و میر ناشی از همه موارد: بررسی منظم و متاآنالیز
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کلمات کلیدی
Cerebral atrophy - آتروفی مغزیwhite matter hyperintensities - ابررایانه ماده سفیدDepression - افسردگیCerebral small vessel disease - بیماری عروق کوچک مغزیDementia - جنون یا زوال عقلStroke - سکته مغزیLacunes - شکافMeta-analysis - فرا تحلیل Perivascular spaces - فضاهای PerivascularSystematic review - مرور سیستماتیکMortality - مرگ ومیرMicrobleeds - میکروبولت
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
MRI features of cerebral small vessel disease (CSVD), i.e. white matter hyperintensities, lacunes, microbleeds, perivascular spaces, and cerebral atrophy, may be associated with clinical events, but the strength of these associations remains unclear. We conducted a systematic review and meta-analysis on the association between these features and incident ischaemic and haemorrhagic stroke, all-cause dementia and depression, and all-cause mortality. For the association with stroke, 36 studies were identified (number of individuals/events [n]â¯=â¯38,432/4,136), for dementia 28 (nâ¯=â¯16,458/1,709), for depression nine (nâ¯=â¯9,538/1,746), and for mortality 28 (nâ¯=â¯23,031/2,558). Only two studies evaluated perivascular spaces; these results were not pooled. Pooled analyses showed that all other features were associated with all outcomes (hazard ratios ranged 1.22-2.72). Combinations of two features were more strongly associated with stroke than any individual feature. Individual features and combinations of CSVD features are strongly associated with incident ischaemic and haemorrhagic stroke, all-cause dementia and depression, and all-cause mortality. If these associations are causal, the strength of these associations suggests that a substantial burden of disease is attributable to CSVD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience & Biobehavioral Reviews - Volume 90, July 2018, Pages 164-173
Journal: Neuroscience & Biobehavioral Reviews - Volume 90, July 2018, Pages 164-173
نویسندگان
Sytze P. Rensma, Thomas T. van Sloten, Lenore J. Launer, Coen D.A. Stehouwer,