کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7303475 | 1475315 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cohesion and the aneuploid phenotype in Alzheimer's disease: A tale of genome instability
ترجمه فارسی عنوان
انعقاد و فنوتیپ آنیوپلوئید در بیماری آلزایمر: داستان ناپایداری ژنوم
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Neurons are postmitotic cells that are in permanent cell cycle arrest. However, components of the cell cycle machinery that are expressed in Alzheimer's disease (AD) neurons are showing features of a cycling cell and those attributed to a postmitotic cell as well. Furthermore, the unique physiological operations taking place in neurons, ascribed to “core cell cycle regulators” are also key regulators in cell division. Functions of these cell cycle regulators include neuronal migration, axonal elongation, axon pruning, dendrite morphogenesis and synaptic maturation and plasticity. In this review, we focus on cohesion and cohesion related proteins in reference to their neuronal functions and how impaired centromere/cohesion dynamics may connect cell cycle dysfunction to aneuploidy in AD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience & Biobehavioral Reviews - Volume 55, August 2015, Pages 365-374
Journal: Neuroscience & Biobehavioral Reviews - Volume 55, August 2015, Pages 365-374
نویسندگان
Vladan Bajic, Biljana Spremo-Potparevic, Lada Zivkovic, Esma R. Isenovic, Thomas Arendt,