Explaining the encoding/retrieval flip: Memory-related deactivations and activations in the posteromedial cortex

► Posteromedial cortex (PMC) deactivates when Encoding and activates when Retrieving. ► Pre-clinical markers of Alzheimer's are linked to PMC changes and the E/R-flip. ► Four neurocognitive accounts are discussed that can possibly explain the E/R-flip. ► Future research on PMC function requires consideration of its functional subregions.