کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
73308 49054 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Applicability of enzyme-responsive mesoporous silica supports capped with bridged silsesquioxane for colon-specific drug delivery
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی کاتالیزور
پیش نمایش صفحه اول مقاله
Applicability of enzyme-responsive mesoporous silica supports capped with bridged silsesquioxane for colon-specific drug delivery
چکیده انگلیسی


• We synthesized a new enzyme-responsive mesoporous silica material.
• The materials showed “zero release” in SGF, SIF or PBS.
• Large amounts of entrapped drugs released in the presence of azo-reductase.
• The material showed excellent behavior for colon specificity.

The necessity and advantages of colon-specific drug delivery systems have been well recognized and documented. In this study, we prepared a new capped mesoporous silica nanoparticle as a potential material for colon-specific drug delivery. This material consisted of nanoscopic mesoporous MCM-41 supports loaded with ibuprofen and capped with a bridged silsesquioxane with azo groups. X-ray diffraction, N2 sorption analysis, transmission electron microscopy, UV–vis diffusion reflectance spectroscopy, and 29Si magic angle spinning nuclear magnetic resonance were used to verify the well-ordered mesostructure and the successful grafting of bridged silsesquioxane on the surface of the mesoporous material. The material showed “zero release” in simulated gastric fluid and simulated intestinal fluid. The opening and release of cargo occurred in simulated colonic fluid with azo-reductase due to the reductive cleavage of the azo bonds. However, no release of ibuprofen was observed in phosphate-buffered saline without enzyme. These results indicated that the capped mesoporous material showed excellent behavior for colon specificity and could be a potential material for colon-specific drug delivery.

A new enzyme-responsive system consisting of mesoporous silica materials as the support and the bridged silsesquioxane as the gate was synthesized to selectively delivery the drug to the colon. The materials showed “zero release” in simulated gastric fluid, simulated intestinal fluid or phosphate-buffered saline. Meanwhile, in the presence of azo reductase, 83 wt% of entrapped drugs was released by 24 h.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microporous and Mesoporous Materials - Volume 184, 15 January 2014, Pages 83–89
نویسندگان
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