Application of orthogonal experimental design in synthesis of mesoporous bioactive glass

• A method combining orthogonal design and quantitive analysis of SAXS was proposed.
• An efficient method to evaluate the impact of multifactor to mesoporous structure.
• The optimum formula of a MBG with complex components was revealed.

An orthogonal experimental design method combining with quantitive analysis of small-angle X-ray scattering (SAXS) pattern was applied to optimize the synthesis of bioactive glasses with highly ordered mesoporous structure (MBGs). The quantitive analysis of SAXS pattern allows a quantified evaluation of the ordering of the mesoporous structure, which makes it possible to tailoring the mesoporous structure of the MBGs with complex component by a traditional orthogonal experimental design method. The number of trials for preparing MBGs can be greatly reduced and the primary factors affecting the formation of mesoporous structure and the properties of MBGs can be easily found out by this orthogonal experimental design method. MBGs containing SiO2, CaO, Fe2O3 were prepared as an example to present the way to obtain optimized ordered mesoporous structure. It confirmed that Fe2O3 was the primary factor influencing the mesoporous structure of the MBGs. The ordering of the mesopores increased in the first and then decreased with the increase of F127 content.

A novel method combining an orthogonal experiment (L16) and a quantitive analysis of SAXS patterns was proposed to reveal the impact degree of multifactor to pore ordering of mesoporous bioactive glasses and determine the optimum synthesis formula of the MBGs with complicated multicomponent. The verification experiment showing the highly ordered mesoporous structure of the optimum MBGs confirmed the rationality and validity of the method.Figure optionsDownload as PowerPoint slide