Mesoporous bioactive glass and glass–ceramics: Influence of the local structure on in vitro bioactivity

• Novel mesoporous bioactive soda-lime phosphosilicate glass and glass–ceramic were synthesized by EISA method.
• The influence of alkaline-earth oxide content on the glass structure and textural properties has become evident.
• An influence of local atomic structure and mesostructure on the HCA formation.

Mesoporous quaternary bioactive glasses and glass–ceramic with alkali–alkaline-earth oxide were successfully synthesized by using non-ionic block copolymer P123 and evaporation induced self assembly (EISA) process followed by acid treatment assisted sol–gel method. As prepared samples has been characterized for the structural, morphological and textural properties with the various analytical techniques. Glass dissolution/ion release rate in simulated body fluid (SBF) was monitored by inductively coupled plasma (ICP) emission spectroscopy, whereas the formation of apatite phase and its crystallization at the glass and glass–ceramic surface was examined by structural, textural and microscopic probes. The influence of alkaline-earth oxide content on the glass structure followed by textural property has become more evident. The pristine glass samples exhibit a wormhole-like mesoporous structure, whereas the glass–ceramic composition is found to be in three different phases, namely crystalline hydroxyapatite, wollastonite and a residual glassy phase as observed in Cerabone® A/W. The existence of calcium orthophosphate phase is closely associated with the pore walls comprising nanometric-sized “inclusions”. The observed high surface area in conjunction with the structural features provides the possible explanation for experimentally observed enhanced bioactivity through the easy access of ions to the fluid. On the other hand, presence of multiple phases in glass–ceramic sample inhibits or delays the kinetics of apatite formation.

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